The Toxic Dose of Nicotine: Shattering the Myth. The initial port of call in any discussion such as this is to address a long-standing myth. To this day, many high-profile sources list the toxic dose of nicotine (the LD50 – or the dose that will kill about half of men and women exposed) as between 30 and 60 mg.
To set this in context of Vapor E Cig, this could be about 4 ml of 12 mg/ml e-liquid. Your system does process nicotine quite quickly (your blood nicotine levels will decrease by about half after 2 hours), so you’d must consume everything basically in one go, which makes it still quite a tall order.
However, research by Bernd Mayer indicates this value for the toxic dose is utterly indefensible. Inside the paper, he details several cases by which people consumed much bigger amounts of nicotine with only minimal symptoms. On top of this, the cheapest quantity of nicotine located in the blood of individuals who died from nicotine was approximately 20 times greater than existing guidelines. Mayer revises the LD50 of nicotine for an estimated 500 to 1000 mg (or .5 to 1 g) on the basis of such results.
The remaining real question is where did the “30 to 60 mg of nicotine will kill you” claim result from? Mayer followed “circular and often misleading references” for a while and ultimately hit on the source: a 1906 textbook coming from a German toxicologist.
On this basis alone, it’s clear that we now have probably some problems with trusting this as being a source. He had been a respected toxicologist during the time, but medical knowledge has advanced massively in the century as it was published, so it isn’t surprising that repeating this claim verbatim without any further analysis isn’t the most effective idea.
The textbook cited some self-experiments performed in the 19th century, where experimenters had the equivalent of a few cigarettes’ worth of nicotine and reported seizures and lack of consciousness. It is going without proclaiming that there was clearly probably some error in measuring out your dose: otherwise chain-smokers would regularly lose consciousness and have seizures.
Signs You’ve Had A Lot Of Nicotine. Vapers aren’t very likely to suffer nicotine poisoning, but one thing that’s fairly common is having a tad too much nicotine in a single sitting. The largest tell-tale sign you’ve reached this point is feeling nauseous. You may notice this right at the end of the long vaping session, and it’s effectively the body telling you to take a break from vaping for quite a while.
Inside my experience, this nausea increases gradually, but it’s advisable to just take a break whenever you notice it starting. By doing this it never becomes too unpleasant, and you also won’t experience the most significant other initial symptom: vomiting. This isn’t tough to avoid in any way, and a lot vapers may have a rest at the first sign of nausea even without having to be advised to do so. You can also obtain a headache if you’ve overdone it a bit, but nausea is the easiest thing to take into consideration.
It’s unlikely you’ll actually be able to this stage by vaping, but it’s worth knowing a few things to look out for. The most serious nicotine poisoning symptoms are even less very likely to occur when you’re vaping, however are worth mentioning anyway. Included in this are coma and seizures (like our 1800s experimenters experienced), slowed heartbeat and in the worst cases, respiratory failure. It might not be as poisonous as numerous sources claim, however it is really still poisonous.
Can You Get Nicotine Poisoning by Vaping? For vapers, the most crucial question is whether this is actually something to worry about in reality. Would you vape your way to a nicotine overdose? Could you end up with some of the much more serious signs of nicotine poisoning?
The easiest way to take into consideration this (and to obtain a straightforward answer!) is to work out just how much e-juice you’d have to vaporize within the space of several hours hitting the minimum toxic dose of about 500 mg.
Utilizing a 12 mg/ml e-juice, you’d have to vaporize over 40 ml to approach 500 mg of nicotine vaporised. Realistically, this just isn’t going to take place. To have an 18 mg/ml e-liquid, you’d still have to vape almost 28 ml of e-juice in a handful of hours to even have a chance.
This is really only step one, though, as well as the nicotine would need to go into the vapour and stay absorbed by your body before it could poison you.
Estimating this aspect is a little tough, but a study from Dr. Farsalinos looked at experienced vapers’ plasma nicotine levels after utilizing a mod and an 18 mg/ml e-liquid. The research didn’t use a modern device, but to reply to the true secret question here it’s more than sufficient. The participants vaped 10 puffs in 5 minutes, then had one hour to djurpj the product however much they liked.
After 5 minutes, experienced vapers wound up with about 8 nanograms (billionths of a gram) of nicotine per ml of blood. Right after the full 65 minutes, vapers plasma nicotine levels rose to 24.1 ng/ml, even though the highest recorded concentration was 48.1 ng/ml.
In Bernd Mayer’s paper, he indicates the minimum plasma concentration recorded from somebody who died from nicotine overdose was 4,000 ng/ml (equal to 4 mg per liter).
Based on the vaper who got the greatest plasma nicotine levels, his or her blood nicotine level would have to be over 80 times higher to reach the minimum lethal dose. To pile on yet more implausibility, they’d have to achieve this in just a couple of hours. Put simply, they’d have to get about 80 times more nicotine in their blood in under twice the length of time.
This ought to clearly show that vapers really can’t overdose on nicotine by using their e-cigarettes as intended. It appears unlikely that it’d be physically easy to inhale the maximum amount of vapour as you’d have to.